Endocrine Abstracts

In this debate I will make an overview of outcomes of NFPA patients with post-operative remnants, who were treated conservatively after surgery. In view of the high rates of tumor progression with consequent need for repeated surgery and radiation therapy, we propose the use of dopamine agonists in these patients. Recent data showing that preventive treatment with dopamine agonists significantly reduces the rate of tumor progression and the need for radiation therapy or additi...

Introduction: Congenital central hypothyroidism (CH), is characterized by low levels of thyroid hormones and TSH. It is not possible to diagnose this condition by neonatal screening programs based on TSH measurements, hence it is often missed. The assumption that CH is usually a mild condition has been refuted, and more than 50% of all newborns with CH have moderate to severe disease. Early diagnosis and treatment lead to better neurodevelopmental outcomes. Isolated CH is a ra...

BackgroundIntravenous levothyroxine (IVT4) is FDA-approved for the treatment of myxedema coma (ME). We noticed that at our hospital, IVT4 is administered more frequently than expected.Aim of studyTo assess the extent of IVT4 administration, the indications for such a treatment, and its outcome at a tertiary facility.MethodsA retrospective study of IVT4 administere...

Background and Aim: We previously demonstrated (1) that in our transgender clinic, adoptees are significantly overrepresented compared to the general population, suggesting early life traumas may play a role in the etiology of transgenderism. We had also shown a large preponderance (close to 80%) of female sex-assigned-at-birth (SAB), and a trend for presenting for treatment at an older age than non-adopted subjects. In the current study we aimed to further characterize this s...

Introduction: Familial Chylomicronemia-FC syndrome is characterized by severely elevated triglyceride levels, i.e., levels of TG above 1000 mg/dl. Monogenic etiology is associated with a small but a significant fraction of Familial Chylomicronemia (FC) Syndrome cases, which is mainly attributed to a few genes, that are involved in Lipoprotein Lipase activity (LPL / LMF1 / APOC2 / GPIHBP1 / APOA5). Bi-allelic variants in these genes cause this rare Autosomal Recessive ...

Background: Immune checkpoint inhibitors (ICPIs) are indicated as treatment for metastatic renal cell carcinoma (RCC) and melanoma, among other malignancies. This group of agents is associated with immune-related adverse events (irAEs). We aimed to further investigate the association of immune-related thyroid disorders (irTDs) with clinical outcomes and mortality rates in patients with RCC or melanoma who were treated with ICPIs.Methods: We retrospective...

Introduction: Spindle cell oncocytoma (SCO), pituicytoma, granular cell tumor, and sellar ependymoma are rare TTF-1 positive posterior pituitary tumors classified as WHO Grade I, indicating low proliferative potential and high rates of surgical cure.Aims: To report a case of SCO and review the pertinent literature.Methods: English and non-English literature was searched, clinical, data were retrieved and summarized.<p class="ab...

We have recently explored the involvement of ghrelin in the eating response to stress in humans and found that ghrelin levels increased in parallel to cortisol after a standardized psychological stress. To further elucidate this interaction, we examined the ghrelin response to pharmacological manipulation of the HPA axis.Following approval from the local Ethical Committee, six lean, healthy male volunteers were examined on two occasions. Blood samples we...

Introduction: Immune check-point inhibitors (ICI) can cause adverse events in many organs due to the activation of T-cells. Data on the effect of ICI on bones and incidence of fracture is still scarce.Aim: To quantify the rate of osteoporotic fracture before and after the use of ICI in cancer patients.Methods: We retrospectively retrieved pertinent data of all patients who were treated with ICI between 2015 and 2023 at the Tel-Aviv...

Serum total cortisol has been linked to increased mortality in patients with Covid-19, but its reliability in critically ill patients is limited. We examined the association between serum free cortisol (SFC) levels and clinical outcomes in patients hospitalized with Covid-19 between 5/5/2020 and 1/3/2021 in our institution. Methods: SFC was measured in blood samples collected at patient’s admission, prior to any medical treatment. Patients’ fil...